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Proliferation and tissue remodeling in cancer: the hallmarks revisited

Author(s): Markert, E.K.; Levine, Arnold J.; Vazquez, A.

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Abstract: Although cancers are highly heterogeneous at the genomic level, they can manifest common patterns of gene expression. Here, we use gene expression signatures to interrogate two major processes in cancer, proliferation and tissue remodeling. We demonstrate that proliferation and remodeling signatures are partially independent and result in four distinctive cancer subtypes. Cancers with the proliferation signature are characterized by signatures of p53 and PTEN inactivation and concomitant Myc activation. In contrast, remodeling correlates with RAS, HIF-1a and NFjB activation. From the metabolic point of view, proliferation is associated with upregulation of glycolysis and serine/glycine metabolism, whereas remodeling is characterized by a downregulation of oxidative phosphorylation. Notably, the proliferation signature correlates with poor outcome in lung, prostate, breast and brain cancer, whereas remodeling increases mortality rates in colorectal and ovarian cancer.
Publication Date: Oct-2012
Electronic Publication Date: 4-Oct-2012
Citation: Markert, EK, Levine, AJ, Vazquez, A. (2012). Proliferation and tissue remodeling in cancer: the hallmarks revisited. Cell Death & Disease, 3 (10), e397 - e397. doi:10.1038/cddis.2012.140
DOI: doi:10.1038/cddis.2012.140
EISSN: 2041-4889
Pages: e397 - e397
Type of Material: Journal Article
Journal/Proceeding Title: Cell Death & Disease
Version: Final published version. This is an open access article.

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