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In vivo models of hepatitis B and C virus infection

Author(s): Winer, Benjamin Y; Ding, Qiang; Gaska, Jenna M; Ploss, Alexander

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dc.contributor.authorWiner, Benjamin Y-
dc.contributor.authorDing, Qiang-
dc.contributor.authorGaska, Jenna M-
dc.contributor.authorPloss, Alexander-
dc.identifier.citationWiner, Benjamin Y, Ding, Qiang, Gaska, Jenna M, Ploss, Alexander. (2016). In vivo models of hepatitis B and C virus infection. FEBS Letters, 590 (13), 1987 - 1999. doi:10.1002/1873-3468.12157en_US
dc.description.abstractGlobally, more than 500 million individuals are chronically infected with hepatitis B (HBV), delta (HDV), and/or C (HCV) viruses, which can result in severe liver disease. Mechanistic studies of viral persistence and pathogenesis have been hampered by the scarcity of animal models. The limited species and cellular host range of HBV, HDV, and HCV, which robustly infect only humans and chimpanzees, have posed challenges for creating such animal models. In this review, we will discuss the barriers to interspecies transmission and the progress that has been made in our understanding of the HBV, HDV, and HCV life cycles. Additionally, we will highlight a variety of approaches that overcome these barriers and thus facilitate in vivo studies of these hepatotropic viruses.en_US
dc.format.extent1987 - 1999en_US
dc.relation.ispartofFEBS Lettersen_US
dc.rightsAuthor's manuscripten_US
dc.titleIn vivo models of hepatitis B and C virus infectionen_US
dc.typeJournal Articleen_US

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