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|Abstract:||Vertebrates exhibit striking left-right (L-R) asymmetries in the structure and position of the internal organs. Symmetry is broken by motile cilia-generated asymmetric fluid flow, resulting in a signaling cascade - the Nodal-Pitx2 pathway - being robustly established within mesodermal tissue on the left side only. This pathway impinges upon various organ primordia to instruct their side-specific development. Recently, progress has been made in understanding both the breaking of embryonic L-R symmetry and how the Nodal-Pitx2 pathway controls lateralized cell differentiation, migration, and other aspects of cell behavior, as well as tissue-level mechanisms, that drive asymmetries in organ formation. Proper execution of asymmetric organogenesis is critical to health, making furthering our understanding of L-R development an important concern.|
|Citation:||Grimes, Daniel T, Burdine, Rebecca D. (2017). Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis.. Trends in genetics : TIG, 33 (9), 616 - 628. doi:10.1016/j.tig.2017.06.004|
|Pages:||1 - 23|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Trends in genetics : TIG|
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