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Asymmetry between Activators and Deactivators in Functional Protein Networks.

Author(s): Tareen, Ammar; Wingreen, Ned; Mukhopadhyay, Ranjan

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Abstract: Are "turn-on" and "turn-off" functions in protein-protein interaction networks exact opposites of each other? To answer this question, we implement a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. We study the roles of activators and deactivators, two core components of oscillatory protein interaction networks, and find a striking asymmetry in the roles of activating and deactivating proteins, where activating proteins tend to be synergistic and deactivating proteins tend to be competitive.
Publication Date: 23-Jun-2020
Electronic Publication Date: 23-Jun-2020
Citation: Tareen, Ammar, Wingreen, Ned S, Mukhopadhyay, Ranjan. (2020). Asymmetry between Activators and Deactivators in Functional Protein Networks.. Scientific Reports, 10 (1), 10131 - 10131. doi:10.1038/s41598-020-66699-y
DOI: doi:10.1038/s41598-020-66699-y
ISSN: 2045-2322
EISSN: 2045-2322
Pages: 10131 - 10131
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Scientific Reports
Version: Final published version. This is an open access article.

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