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Compartmentalized oskar degradation in the germ plasm safeguards germline development

Author(s): Eichler, Catherine E; Hakes, Anna C; Hull, Brooke; Gavis, Elizabeth R

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Abstract: Partitioning of mRNAs into ribonucleoprotein (RNP) granules supports diverse regulatory programs within the crowded cytoplasm. At least two types of RNP granules populate the germ plasm, a cytoplasmic domain at the posterior of the Drosophila oocyte and embryo. Germ granules deliver mRNAs required for germline development to pole cells, the germ cell progenitors. A second type of RNP granule, here named founder granules, contains oskar mRNA, which encodes the germ plasm organizer. Whereas oskar mRNA is essential for germ plasm assembly during oogenesis, we show that it is toxic to pole cells. Founder granules mediate compartmentalized degradation of oskar during embryogenesis to minimize its inheritance by pole cells. Degradation of oskar in founder granules is temporally and mechanistically distinct from degradation of oskar and other mRNAs during the maternal-to-zygotic transition. Our results show how compartmentalization in RNP granules differentially controls fates of mRNAs localized within the same cytoplasmic domain.
Publication Date: 7-Jan-2020
Citation: Eichler, Catherine E, Hakes, Anna C, Hull, Brooke, Gavis, Elizabeth R. (2020). Compartmentalized oskar degradation in the germ plasm safeguards germline development.. eLife, 9. doi:10.7554/elife.49988
DOI: doi:10.7554/elife.49988
ISSN: 2050-084X
EISSN: 2050-084X
Pages: e49988 - e49988
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: eLife
Version: Final published version. This is an open access article.

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