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The Bam machine: A molecular cooper

Author(s): Ricci, Dante P; Silhavy, Thomas J

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Abstract: The bacterial outer membrane (OM) is an exceptional biological structure with a unique composition that contributes significantly to the resiliency of Gram-negative bacteria. Since all OM components are synthesized in the cytosol, the cell must efficiently transport OM-specific lipids and proteins across the cell envelope and stably integrate them into a growing membrane. In this review, we discuss the challenges associated with these processes and detail the elegant solutions that cells have evolved to address the topological problem of OM biogenesis. Special attention will be paid to the Bam machine, a highly conserved multiprotein complex that facilitates OM β-barrel folding.
Publication Date: Apr-2012
Citation: Ricci, Dante P, Silhavy, Thomas J. (2012). The Bam machine: A molecular cooper. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818 (4), 1067 - 1084. doi:10.1016/j.bbamem.2011.08.020
DOI: doi:10.1016/j.bbamem.2011.08.020
ISSN: 0005-2736
Pages: 1067 - 1084
Type of Material: Journal Article
Journal/Proceeding Title: Biochimica et Biophysica Acta (BBA) - Biomembranes
Version: Author's manuscript

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