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The cell biology of planar cell polarity

Author(s): Devenport, Danelle

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Abstract: Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between neighboring cells. Recent progress has been made toward understanding how protein transport, endocytosis, and intercellular interactions contribute to asymmetric PCP protein localization. Additionally, the functions of gradients and mechanical forces as global cues that bias PCP orientation are beginning to be elucidated. Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level.
Publication Date: 27-Oct-2014
Electronic Publication Date: 27-Oct-2014
Citation: Devenport, Danelle. (2014). The cell biology of planar cell polarity. The Journal of Cell Biology, 207 (2), 171 - 179. doi:10.1083/jcb.201408039
DOI: doi:10.1083/jcb.201408039
ISSN: 0021-9525
EISSN: 1540-8140
Pages: 1 - 10
Type of Material: Journal Article
Journal/Proceeding Title: The Journal of Cell Biology
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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