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The genome of a subterrestrial nematode reveals adaptations to heat

Author(s): Weinstein, Deborah J; Allen, Sarah E; Lau, Maggie CY; Erasmus, Mariana; Asalone, Kathryn C; et al

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Abstract: The nematode Halicephalobus mephisto was originally discovered inhabiting a deep terrestrial aquifer 1.3‚ÄČkm underground. H. mephisto can thrive under conditions of abiotic stress including heat and minimal oxygen, where it feeds on a community of both chemolithotrophic and heterotrophic prokaryotes in an unusual ecosystem isolated from the surface biosphere. Here we report the comprehensive genome and transcriptome of this organism, identifying a signature of adaptation: an expanded repertoire of 70 kilodalton heat-shock proteins (Hsp70) and avrRpt2 induced gene 1 (AIG1) proteins. The expanded Hsp70 genes are transcriptionally induced upon growth under heat stress, and we find that positive selection is detectable in several members of this family. We further show that AIG1 may have been acquired by horizontal gene transfer (HGT) from a rhizobial fungus. Over one-third of the genes of H. mephisto are novel, highlighting the divergence of this nematode from other sequenced organisms. This work sheds light on the genomic basis of heat tolerance in a complete subterrestrial eukaryotic genome.
Publication Date: 21-Nov-2019
Citation: Weinstein, Deborah J., Sarah E. Allen, Maggie C.Y. Lau, Mariana Erasmus, Kathryn C. Asalone, Kathryn Walters-Conte, Gintaras Deikus et al. "The genome of a subterrestrial nematode reveals adaptations to heat." Nature Communications 10, no. 1 (2019): 1-14. doi:10.1038/s41467-019-13245-8.
DOI: doi:10.1038/s41467-019-13245-8
EISSN: 2041-1723
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Pages: 1 - 14
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Nature Communications
Version: Final published version. This is an open access article.
Notes: Related Item links to supplementary material associated with journal article.

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