Skip to main content

Mechanical instability and interfacial energy drive biofilm morphogenesis.

Author(s): Yan, Jing; Fei, Chenyi; Mao, Sheng; Moreau, Alexis; Wingreen, Ned S; et al

To refer to this page use:
Abstract: Surface-attached bacterial communities called biofilms display a diversity of morphologies. Although structural and regulatory components required for biofilm formation are known, it is not understood how these essential constituents promote biofilm surface morphology. Here, using Vibrio cholerae as our model system, we combine mechanical measurements, theory and simulation, quantitative image analyses, surface energy characterizations, and mutagenesis to show that mechanical instabilities, including wrinkling and delamination, underlie the morphogenesis program of growing biofilms. We also identify interfacial energy as a key driving force for mechanomorphogenesis because it dictates the generation of new and the annihilation of existing interfaces. Finally, we discover feedback between mechanomorphogenesis and biofilm expansion, which shapes the overall biofilm contour. The morphogenesis principles that we discover in bacterial biofilms, which rely on mechanical instabilities and interfacial energies, should be generally applicable to morphogenesis processes in tissues in higher organisms.
Publication Date: 8-Mar-2019
Citation: Yan, Jing, Fei, Chenyi, Mao, Sheng, Moreau, Alexis, Wingreen, Ned S, Košmrlj, Andrej, Stone, Howard A, Bassler, Bonnie L. (2019). Mechanical instability and interfacial energy drive biofilm morphogenesis.. eLife, 8 (10.7554/eLife.43920
DOI: doi:10.7554/eLife.43920
ISSN: 2050-084X
EISSN: 2050-084X
Pages: 1 - 28
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: eLife
Version: Final published version. This is an open access article.

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.