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Envelope Stress Responses: An Interconnected Safety Net

Author(s): Grabowicz, Marcin; Silhavy, Thomas J

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Abstract: The Escherichia coli cell envelope is a protective barrier at the frontline of interaction with the environment. Fidelity of envelope biogenesis must be monitored to establish and maintain a contiguous barrier. Indeed, the envelope must also be repaired and modified in response to environmental assaults. Envelope stress responses (ESRs) sense envelope damage or defects and alter the transcriptome to mitigate stress. We will review recent insights into stress sensing mechanisms of the σE and Cpx systems and the interaction of these ESRs. Small RNAs (sRNAs) are increasingly prominent regulators of the transcriptional response to stress. These fast-acting regulators also provide avenues for inter-ESR regulation that could be important when cells face multiple contemporaneous stresses, as is the case during infection.
Publication Date: Mar-2017
Citation: Grabowicz, Marcin, Silhavy, Thomas J. (2017). Envelope Stress Responses: An Interconnected Safety Net. Trends in Biochemical Sciences, 42 (3), 232 - 242. doi:10.1016/j.tibs.2016.10.002
DOI: doi:10.1016/j.tibs.2016.10.002
ISSN: 0968-0004
Pages: 232 - 242
Type of Material: Journal Article
Journal/Proceeding Title: Trends in Biochemical Sciences
Version: Author's manuscript

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