Skip to main content

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

Author(s): Okuda, Suguru; Sherman, David J; Silhavy, Thomas J; Ruiz, Natividad; Kahne, Daniel

To refer to this page use:
Abstract: Gram-negative bacteria contain a double-membrane cellular envelope that enables them to colonize harsh environments and prevents entry of many clinically available antibiotics. A main component of most outer membranes is lipopolysaccharide (LPS), a glycolipid containing multiple fatty acyl chains and up to hundreds of sugars that is synthesized in the cytoplasm. In the last two decades, the proteins responsible for transporting LPS across the cellular envelope and assembling it at the cell surface in Escherichia coli have been identified, but it remains unclear how they function. In this Review, we discuss recent advances in this area and present a model explaining how energy from the cytoplasm is used to power LPS transport across the cellular envelope to the cell surface.
Publication Date: Jun-2016
Electronic Publication Date: 30-Mar-2016
Citation: Okuda, Suguru, Sherman, David J, Silhavy, Thomas J, Ruiz, Natividad, Kahne, Daniel. (2016). Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model. Nature Reviews Microbiology, 14 (6), 337 - 345. doi:10.1038/nrmicro.2016.25
DOI: doi:10.1038/nrmicro.2016.25
ISSN: 1740-1526
EISSN: 1740-1534
Pages: 337 - 345
Type of Material: Journal Article
Journal/Proceeding Title: Nature Reviews Microbiology
Version: Author's manuscript

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.