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Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.

Author(s): Perera, Jason; Zheng, Zhong; Li, Shuyin; Gudjonson, Herman; Kalinina, Olga; et al

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Abstract: B cells are unique antigen-presenting cells because their antigen presentation machinery is closely tied to the B cell receptor. Autoreactive thymic B cells can efficiently present cognate self-antigens to mediate CD4+ T cell-negative selection. However, the nature of thymocyte-thymic B cell interaction and how this interaction affects the selection of thymic B cell repertoire and, in turn, the T cell repertoire are not well understood. Here we demonstrate that a large percentage of thymic B cells have undergone class switching intrathymically. Thymic B cell class switching requires cognate interaction with specific T cells. Class-switched thymic B cells have a distinct repertoire compared with unswitched thymic B cells or splenic B cells. Particularly, autoreactive B cell specificities preferentially expand in the thymus by undergoing class switching, and these enriched, class-switched autoreactive thymic B cells play an important role in CD4 T cell tolerance.
Publication Date: 4-Oct-2016
Citation: Perera, Jason, Zheng, Zhong, Li, Shuyin, Gudjonson, Herman, Kalinina, Olga, Benichou, Jennifer IC, Block, Katharine E, Louzoun, Yoram, Yin, Dengping, Chong, Anita S, Dinner, Aaron R, Weigert, Martin, Huang, Haochu. (2016). Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.. Cell reports, 17 (2), 387 - 398. doi:10.1016/j.celrep.2016.09.011
DOI: doi:10.1016/j.celrep.2016.09.011
ISSN: 2211-1247
EISSN: 2211-1247
Pages: 1 - 13
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Cell reports
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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