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Activation of Gαq Signaling Enhances Memory Consolidation and Slows Cognitive Decline

Author(s): Arey, Rachel N; Stein, Geneva M; Kaletsky, Rachel; Kauffman, Amanda; Murphy, Coleen T

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dc.contributor.authorArey, Rachel N-
dc.contributor.authorStein, Geneva M-
dc.contributor.authorKaletsky, Rachel-
dc.contributor.authorKauffman, Amanda-
dc.contributor.authorMurphy, Coleen T-
dc.identifier.citationArey, Rachel N, Stein, Geneva M, Kaletsky, Rachel, Kauffman, Amanda, Murphy, Coleen T. (2018). Activation of Gαq Signaling Enhances Memory Consolidation and Slows Cognitive Decline. Neuron, 98 (3), 562 - 574.e5. doi:10.1016/j.neuron.2018.03.039en_US
dc.description.abstractPerhaps the most devastating decline with age is the loss of memory. Therefore, identifying mechanisms to restore memory function with age is critical. Using C. elegans associative learning and memory assays, we identified a gain-of-function Gαq signaling pathway mutant that forms a long-term (cAMP response element binding protein [CREB]-dependent) memory following one conditioned stimulus-unconditioned stimulus (CS-US) pairing, which usually requires seven CS-US pairings. Increased CREB activity in AIM interneurons reduces the threshold for memory consolidation through transcription of a set of previously identified "long-term memory" genes. Enhanced Gαq signaling in the AWC sensory neuron is both necessary and sufficient for improved memory and increased AIM CREB activity, and activation of Gαq specifically in aged animals rescues the ability to form memory. Activation of Gαq in AWC sensory neurons non-cell autonomously induces consolidation after one CS-US pairing, enabling both cognitive function maintenance with age and restoration of memory function in animals with impaired memory performance without decreased longevity.en_US
dc.format.extent562 - 574.e5en_US
dc.rightsAuthor's manuscripten_US
dc.titleActivation of Gαq Signaling Enhances Memory Consolidation and Slows Cognitive Declineen_US
dc.typeJournal Articleen_US

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