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Building the Microtubule Cytoskeleton Piece by Piece

Author(s): Alfaro-Aco, Ray; Petry, Sabine

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Abstract: The microtubule (MT) cytoskeleton gives cells their shape, organizes the cellular interior, and segregates chromosomes. These functions rely on the precise arrangement of MTs, which is achieved by the coordinated action of MT-associated proteins (MAPs). We highlight the first and most important examples of how different MAP activities are combined in vitro to create an ensemble function that exceeds the simple addition of their individual activities, and how the Xenopus laevis egg extract system has been utilized as a powerful intermediate between cellular and purified systems to uncover the design principles of self-organized MT networks in the cell.
Publication Date: 10-Jul-2015
DOI: doi:10.1074/jbc.r115.638452
ISSN: 0021-9258
Language: en
Type of Material: Journal Article
Journal/Proceeding Title: The Journal of Biological Chemistry
Version: Final published version. This is an open access article.

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