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|Abstract:||Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process and show that energy dissipation cannot circumvent the fundamental tradeoff, so that the SNR is still optimal for independent receptors. For systems requiring high gain, nonequilibrium 2D-coupled receptors maximize the SNR, revealing a new design principle for biological sensors.|
|Citation:||Skoge, Monica, Naqvi, Sahin, Meir, Yigal, Wingreen, Ned S. (2013). Chemical Sensing by Nonequilibrium Cooperative Receptors. Phys Rev Lett, 110 (24), 10.1103/PhysRevLett.110.|
|Pages:||248102 - 248102|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Physical Review Letters|
|Version:||Final published version. Article is made available in OAR by the publisher's permission or policy.|
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