Skip to main content

Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors.

Author(s): Streichan, Sebastian J; Lefebvre, Matthew F; Noll, Nicholas; Wieschaus, Eric F; Shraiman, Boris I

Download
To refer to this page use: http://arks.princeton.edu/ark:/88435/pr1cc65
Full metadata record
DC FieldValueLanguage
dc.contributor.authorStreichan, Sebastian J-
dc.contributor.authorLefebvre, Matthew F-
dc.contributor.authorNoll, Nicholas-
dc.contributor.authorWieschaus, Eric F-
dc.contributor.authorShraiman, Boris I-
dc.date.accessioned2022-01-25T14:48:17Z-
dc.date.available2022-01-25T14:48:17Z-
dc.date.issued2018-02-09en_US
dc.identifier.citationStreichan, Sebastian J., Matthew F. Lefebvre, Nicholas Noll, Eric F. Wieschaus, and Boris I. Shraiman. "Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors." Elife 7 (2018): e27454.en_US
dc.identifier.issn2050-084X-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1cc65-
dc.description.abstractDuring embryogenesis tissue layers undergo morphogenetic flow rearranging and folding into specific shapes. While developmental biology has identified key genes and local cellular processes, global coordination of tissue remodeling at the organ scale remains unclear. Here, we combine in toto light-sheet microscopy of the Drosophila embryo with quantitative analysis and physical modeling to relate cellular flow with the patterns of force generation during the gastrulation process. We find that the complex spatio-temporal flow pattern can be predicted from the measured meso-scale myosin density and anisotropy using a simple, effective viscous model of the tissue, achieving close to 90% accuracy with one time dependent and two constant parameters. Our analysis uncovers the importance of a) spatial modulation of myosin distribution on the scale of the embryo and b) the non-locality of its effect due to mechanical interaction of cells, demonstrating the need for the global perspective in the study of morphogenetic flow.en_US
dc.format.extente27454 - e27454en_US
dc.languageengen_US
dc.language.isoen_USen_US
dc.relation.ispartofeLifeen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleGlobal morphogenetic flow is accurately predicted by the spatial distribution of myosin motors.en_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.7554/elife.27454-
dc.date.eissued2018-02-09en_US
dc.identifier.eissn2050-084X-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

Files in This Item:
File Description SizeFormat 
global_morphogenetic_spatial_myosin.pdf3.62 MBAdobe PDFView/Download


Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.