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|Abstract:||Host-microbial symbioses are vital to health; nonetheless, little is known about the role cross-kingdom signaling plays in these relationships. In a process called quorum sensing, bacteria communicate with one another using extracellular signal molecules called autoinducers. One autoinducer, AI-2, is proposed to promote inter-species bacterial communication, including in the mammalian gut. We show that mammalian epithelia produce an AI-2 mimic activity in response to bacteria or tight-junction disruption. This AI-2 mimic is detected by the bacterial AI-2 receptor, LuxP/LsrB, and can activate quorum-sensing-controlled gene expression, including in the enteric pathogen Salmonella typhimurium. AI-2 mimic activity is induced when epithelia are directly or indirectly exposed to bacteria, suggesting that a secreted bacterial component(s) stimulates its production. Mutagenesis revealed genes required for bacteria to both detect and stimulate production of the AI-2 mimic. These findings uncover a potential role for the mammalian AI-2 mimic in fostering cross-kingdom signaling and host-bacterial symbioses.|
|Citation:||Ismail, Anisa S, Valastyan, Julie S, Bassler, Bonnie L. (2016). A Host-Produced Autoinducer-2 Mimic Activates Bacterial Quorum Sensing. Cell Host & Microbe, 19 (4), 470 - 480. doi:10.1016/j.chom.2016.02.020|
|Pages:||1 - 25|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Cell Host & Microbe|
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