Skip to main content

Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks

Author(s): Chetverina, Darya; Aoki, Tsutomu; Erokhin, Maksim; Georgiev, Pavel; Schedl, Paul

To refer to this page use:
Abstract: Insulators play a central role in subdividing the chromosome into a series of discrete topologically independent domains and in ensuring that enhancers and silencers contact their appropriate target genes. In this review we first discuss the general characteristics of insulator elements and their associated protein factors. A growing collection of insulator proteins have been identified including a family of proteins whose expression is developmentally regulated. We next consider several unexpected discoveries that require us to completely rethink how insulators function (and how they can best be assayed). These discoveries also require a reevaluation of how insulators might restrict or orchestrate (by preventing or promoting) interactions between regulatory elements and their target genes. We conclude by connecting these new insights into the mechanisms of insulator action to dynamic changes in the three-dimensional topology of the chromatin fiber and the generation of specific patterns of gene activity during development and differentiation.
Publication Date: Feb-2014
Citation: Chetverina, Darya, Aoki, Tsutomu, Erokhin, Maksim, Georgiev, Pavel, Schedl, Paul. (2014). Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.. BioEssays, 36 (2), 163 - 172. doi:10.1002/bies.201300125
DOI: doi:10.1002/bies.201300125
ISSN: 0265-9247
EISSN: 1521-1878
Pages: 163 - 172
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: BioEssays
Version: Author's manuscript

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.