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Mating and male pheromone kill Caenorhabditis males through distinct mechanisms

Author(s): Shi, Cheng; Runnels, Alexi M; Murphy, Coleen T

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Abstract: Differences in longevity between sexes is a mysterious yet general phenomenon across great evolutionary distances. To test the roles of responses to environmental cues and sexual behaviors in longevity regulation, we examined Caenorhabditis male lifespan under solitary, grouped, and mated conditions. We find that neurons and the germline are required for male pheromone-dependent male death. Hermaphrodites with a masculinized nervous system secrete male pheromone and are susceptible to male pheromone killing. Male pheromone-mediated killing is unique to androdioecious Caenorhabditis, and may reduce the number of males in hermaphroditic populations; neither males nor females of gonochoristic species are susceptible to male pheromone killing. By contrast, mating-induced death, which is characterized by germlinedependent shrinking, glycogen loss, and ectopic vitellogenin expression, utilizes distinct molecular pathways and is shared between the sexes and across species. The study of sex- and speciesspecific regulation of aging reveals deeply conserved mechanisms of longevity and population structure regulation.
Publication Date: 14-Mar-2017
Electronic Publication Date: 14-Mar-2017
Citation: Shi, Cheng, Runnels, Alexi M, Murphy, Coleen T. (2017). Mating and male pheromone kill Caenorhabditis males through distinct mechanisms. eLife, 6 (10.7554/eLife.23493
DOI: doi:10.7554/eLife.23493
EISSN: 2050-084X
Pages: e23493 - e23493
Type of Material: Journal Article
Journal/Proceeding Title: eLife
Version: Final published version. This is an open access article.

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