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Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma

Author(s): Puzio-Kuter, A.M.; Laddha, S.V.; Castillo-Martin, M.; Sun, Y.; Cordon-Cardo, C.; et al

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Abstract: Liposarcoma (LPS) is a type of soft tissue sarcoma that mostly occurs in adults, and in humans is characterized by amplifications of MDM2 and CDK4. The molecular pathogenesis of this malignancy is still poorly understood and, therefore, we developed a mouse model with conditional inactivation of PTEN and p53 to investigate these pathways in the progression of the disease. We show that deletion of these two tumor suppressors cooperate in the formation of multiple subtypes of LPS (from well-differentiated LPS to pleomorphic LPS). In addition, progression of the tumors is further characterized by the expression of D cyclins and CDK4/6, which allow for continued cell division. Microarray analysis also revealed novel genes that are differentially expressed between different subtypes of LPS, which could aid in understanding the disease and to unravel potential new therapeutic targets.
Publication Date: Nov-2015
Electronic Publication Date: 27-Mar-2015
Citation: Puzio-Kuter, AM, Laddha, SV, Castillo-Martin, M, Sun, Y, Cordon-Cardo, C, Chan, CS, Levine, AJ. (2015). Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. Cell Death & Differentiation, 22 (11), 1785 - 1791. doi:10.1038/cdd.2015.27
DOI: doi:10.1038/cdd.2015.27
ISSN: 1350-9047
EISSN: 1476-5403
Pages: 1785 - 1791
Type of Material: Journal Article
Journal/Proceeding Title: Cell Death & Differentiation
Version: Final published version. This is an open access article.

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