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Illuminating developmental biology with cellular optogenetics.

Author(s): Johnson, Heath E; Toettcher, Jared E

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Abstract: In developmental biology, localization is everything. The same stimulus –a cell signaling event or expression of a gene – can have dramatically different effects depending on the time, spatial position, and cell types in which it is applied. Yet the field has long lacked the ability to deliver localized perturbations with high specificity in vivo. The advent of optogenetic tools, capable of delivering highly localized stimuli, is thus poised to profoundly expand our understanding of development. We describe the current state-of-the-art in cellular optogenetic tools, review the first wave of major studies showcasing their application in vivo, and discuss major obstacles that must be overcome if the promise of developmental optogenetics is to be fully realized.
Electronic Publication Date: 2-Mar-2018
Citation: Johnson, Heath E, Toettcher, Jared E. (2018). Illuminating developmental biology with cellular optogenetics.. Current opinion in biotechnology, 52 (42 - 48. doi:10.1016/j.copbio.2018.02.003).
DOI: doi:10.1016/j.copbio.2018.02.003
ISSN: 0958-1669
EISSN: 1879-0429
Pages: 42 - 48
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Current Opinion in Biotechnology
Version: Author's manuscript

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