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Mating Induces Shrinking and Death in Caenorhabditis Mothers

Author(s): Shi, C; Murphy, CT

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Abstract: Interactions between the germ line and the soma help optimize reproductive success. We discovered a phenomenon linking reproductive status to longevity: In both hermaphroditic and gonochoristic Caenorhabditis, mating leads to female shrinking and death, compressing postreproductive life span. Male sperm induces germline- and DAF-9/DAF-12-dependent shrinking, osmotic stress susceptibility, and subsequent life-span decrease, whereas seminal fluid induces DAF-16-dependent life-span decrease and fat loss. Our study provides insight into the communication between males and the female germ line and soma to regulate reproduction and longevity, revealing a high-reproduction, low-life-span state induced by mating. Postmating somatic collapse may be an example of the sexually antagonistic influence that males in many species exert on female behavior to maximize their own reproductive success.
Publication Date: 31-Jan-2014
Electronic Publication Date: 19-Dec-2013
Citation: Shi, C, Murphy, CT. (2014). Mating Induces Shrinking and Death in Caenorhabditis Mothers. Science, 343 (6170), 536 - 540. doi:10.1126/science.1242958
DOI: doi:10.1126/science.1242958
ISSN: 0036-8075
EISSN: 1095-9203
Pages: 536 - 540
Type of Material: Journal Article
Journal/Proceeding Title: Science
Version: Author's manuscript

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