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Making a membrane on the other side of the wall

Author(s): May, Kerrie L; Silhavy, Thomas J

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Abstract: The outer membrane (OM) of Gram-negative bacteria is positioned at the frontline of the cell’s interaction with its environment and provides a barrier against influx of external toxins while still allowing import of nutrients and excretion of wastes. It is a remarkable asymmetric bilayer with a glycolipid surface-exposed leaflet and a glycerophospholipid inner leaflet. Lipid asymmetry is key to OM barrier function and several different systems actively maintain this lipid asymmetry. All OM components are synthesized in the cytosol before being secreted and assembled into a contiguous membrane on the other side of the cell wall. Work in recent years has uncovered the pathways that transport and assemble most of the OM components. However, our understanding of how phospholipids are delivered to the OM remains notably limited. Here we will review seminal works in phospholipid transfer performed some 40 years ago and place more recent insights in their context.
Publication Date: Nov-2017
Citation: May, Kerrie L, Silhavy, Thomas J. (2017). Making a membrane on the other side of the wall. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1862 (11), 1386 - 1393. doi:10.1016/j.bbalip.2016.10.004
DOI: doi:10.1016/j.bbalip.2016.10.004
ISSN: 1388-1981
Pages: 1386 - 1393
Type of Material: Journal Article
Journal/Proceeding Title: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Version: Author's manuscript

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