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Decoding locomotion from population neural activity in moving C. elegans

Author(s): Hallinen, Kelsey M; Dempsey, Ross; Scholz, Monika; Yu, Xinwei; Linder, Ashley; et al

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dc.contributor.authorHallinen, Kelsey M-
dc.contributor.authorDempsey, Ross-
dc.contributor.authorScholz, Monika-
dc.contributor.authorYu, Xinwei-
dc.contributor.authorLinder, Ashley-
dc.contributor.authorRandi, Francesco-
dc.contributor.authorSharma, Anuj K-
dc.contributor.authorShaevitz, Joshua W-
dc.contributor.authorLeifer, Andrew M-
dc.date.accessioned2025-03-04T19:59:50Z-
dc.date.available2025-03-04T19:59:50Z-
dc.date.issued2021-07-29en_US
dc.identifier.citationHallinen, Kelsey M, Dempsey, Ross, Scholz, Monika, Yu, Xinwei, Linder, Ashley, Randi, Francesco, Sharma, Anuj K, Shaevitz, Joshua W, Leifer, Andrew M. (Decoding locomotion from population neural activity in moving C. elegans. eLife, 10 (10.7554/elife.66135en_US
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr16w9692f-
dc.description.abstractWe investigated the neural representation of locomotion in the nematode C. elegans by recording population calcium activity during movement. We report that population activity more accurately decodes locomotion than any single neuron. Relevant signals are distributed across neurons with diverse tunings to locomotion. Two largely distinct subpopulations are informative for decoding velocity and curvature, and different neurons’ activities contribute features relevant for different aspects of a behavior or different instances of a behavioral motif. To validate our measurements, we labeled neurons AVAL and AVAR and found that their activity exhibited expected transients during backward locomotion. Finally, we compared population activity during movement and immobilization. Immobilization alters the correlation structure of neural activity and its dynamics. Some neurons positively correlated with AVA during movement become negatively correlated during immobilization and vice versa. This work provides needed experimental measurements that inform and constrain ongoing efforts to understand population dynamics underlying locomotion in C. elegans.en_US
dc.languageenen_US
dc.relation.ispartofeLifeen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleDecoding locomotion from population neural activity in moving C. elegansen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.7554/elife.66135-
dc.date.eissued2021-07-29en_US
dc.identifier.eissn2050-084X-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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