Skip to main content

Context-dependent EMT programs in cancer metastasis.

Author(s): Aiello, Nicole M; Kang, Yibin

To refer to this page use:
Abstract: Epithelial-mesenchymal transition (EMT) is a developmental process whereby stationary, adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements during embryogenesis; however, tumor cells can reactivate EMT programs, which increases their aggressiveness. In addition to motility, EMT is associated with enhanced stem cell properties and drug resistance; thus it can drive metastasis, tumor recurrence, and therapy resistance in the context of cancer. However, the precise requirements for EMT in metastasis have not been fully delineated, with different tumor types relying on discrete EMT effectors. Most tumor cells do not undergo a full EMT, but rather adopt some qualities of mesenchymal cells and maintain some epithelial characteristics. Emerging evidence suggests that partial EMT can drive distinct migratory properties and enhance the epithelial-mesenchymal plasticity of cancer cells as well as cell fate plasticity. This review discusses the diverse regulatory mechanisms and functional consequences of EMT, with an emphasis on the importance of partial EMT.
Publication Date: May-2019
Electronic Publication Date: 11-Apr-2019
Citation: Aiello, Nicole M, Kang, Yibin. (2019). Context-dependent EMT programs in cancer metastasis.. The Journal of experimental medicine, 216 (5), 1016 - 1026. doi:10.1084/jem.20181827
DOI: doi:10.1084/jem.20181827
ISSN: 0022-1007
EISSN: 1540-9538
Pages: 1 - 11
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: The Journal of experimental medicine
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.