Skip to main content

Ets2 anchors the prometastatic function of mutant p53 in osteosarcoma.

Author(s): Liu, Daniel D; Kang, Yibin

Download
To refer to this page use: http://arks.princeton.edu/ark:/88435/pr1519j
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLiu, Daniel D-
dc.contributor.authorKang, Yibin-
dc.date.accessioned2020-02-25T20:10:54Z-
dc.date.available2020-02-25T20:10:54Z-
dc.date.issued2017-09en_US
dc.identifier.citationLiu, Daniel D, Kang, Yibin. (2017). Ets2 anchors the prometastatic function of mutant p53 in osteosarcoma.. Genes & development, 31 (18), 1823 - 1824. doi:10.1101/gad.307439.117en_US
dc.identifier.issn0890-9369-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1519j-
dc.description.abstractMutations in the tumor suppressor p53 occur in a majority of human cancers. Some gain-of-function (GOF) p53 mutations endow tumor cells with increased metastatic ability, although our understanding of the underlying mechanism remains incomplete. In this issue of Genes & Development, Pourebrahim and colleagues (pp. 1847-1857) develop a new mouse model of osteosarcoma in which a GOF mutant p53 allele is expressed specifically in osteoblasts, while the tumor microenvironment remains wild type for p53, allowing for the study of cell-autonomous functions. In this model, the role of GOF mutant p53 in promoting lung metastasis is shown to be critically dependent on the transcription factor Ets2 and is accompanied by the elevated expression of a cluster of small nucleolar RNAs (snoRNAs).en_US
dc.format.extent1 - 3en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofGenes & developmenten_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleEts2 anchors the prometastatic function of mutant p53 in osteosarcoma.en_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1101/gad.307439.117-
dc.identifier.eissn1549-5477-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

Files in This Item:
File Description SizeFormat 
Ets2 anchors the prometastatic function of mutant p53 in osteosarcoma.pdf288.81 kBAdobe PDFView/Download


Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.