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Detection of a common chimeric transcript between human chromosomes 7 and 16

Author(s): Fang, Wenwen; Wei, Yong; Kang, Yibin; Landweber, Laura F

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Abstract: Interchromosomal chimeric RNA molecules are often transcription products from genomic rearrangement in cancerous cells. Here we report the computational detection of an interchromosomal RNA fusion between ZC3HAV1L and CHMP1A from RNA-seq data of normal human mammary epithelial cells, and experimental confirmation of the chimeric transcript in multiple human cells and tissues. Our experimental characterization also detected three variants of the ZC3HAV1L-CHMP1A chimeric RNA, suggesting that these genes are involved in complex splicing. The fusion sequence at the novel exon-exon boundary, and the absence of corresponding DNA rearrangement suggest that this chimeric RNA is likely produced by trans-splicing in human cells.
Publication Date: 2012
Citation: Fang, Wenwen, Wei, Yong, Kang, Yibin, Landweber, Laura F. (2012). Detection of a common chimeric transcript between human chromosomes 7 and 16. Biology Direct, 7 (1), 49 - 49. doi:10.1186/1745-6150-7-49
DOI: doi:10.1186/1745-6150-7-49
ISSN: 1745-6150
Pages: 1 - 6
Type of Material: Journal Article
Journal/Proceeding Title: Biology Direct
Version: Final published version. This is an open access article.

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