Skip to main content

All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models

Author(s): Posfai, Eszter; Lanner, Fredrik; Mulas, Carla; Leitch, Harry G

To refer to this page use:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPosfai, Eszter-
dc.contributor.authorLanner, Fredrik-
dc.contributor.authorMulas, Carla-
dc.contributor.authorLeitch, Harry G-
dc.description.abstractDetailed studies of the embryo allow an increasingly mechanistic understanding of development, which has proved of profound relevance to human disease. The last decade has seen in vitro cultured stem cell-based models of embryo development flourish, which provide an alternative to the embryo for accessible experimentation. However, the usefulness of any stem cell-based embryo model will be determined by how accurately it reflects in vivo embryonic development, and/or the extent to which it facilitates new discoveries. Stringent benchmarking of embryo models is thus an important consideration for this growing field. Here we provide an overview of means to evaluate both the properties of stem cells, the building blocks of most embryo models, as well as the usefulness of current and future in vitro embryo models.en_US
dc.relation.ispartofStem Cell Reportsen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleAll models are wrong, but some are useful: Establishing standards for stem cell-based embryo modelsen_US
dc.typeJournal Articleen_US

Files in This Item:
File Description SizeFormat 
All models are wrong, but some are useful- Establishing standards for stem cell-based embryo models.pdf35.04 MBAdobe PDFView/Download

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.