Skip to main content

Cerebellar disruption impairs working memory during evidence accumulation

Author(s): Deverett, Ben; Kislin, Mikhail; Tank, David W; Wang, Samuel S-H

To refer to this page use:
Abstract: To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduces the accuracy of subsequent memory-guided decisions and causes mice to downweight prior information. Behavioral deficits are consistent with the addition of noise and leak to the evidence accumulation process. We conclude that the cerebellum can influence the accurate maintenance of working memory.
Publication Date: 16-Jul-2019
Citation: Deverett, B., Kislin, M., Tank, D. W., & Wang, S. S. -. (2019). Cerebellar disruption impairs working memory during evidence accumulation. Nature Communications, 10, 1-7. doi:
Type of Material: Journal Article
Journal/Proceeding Title: Nature Communications
Version: Final published version. This is an open access article.

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.