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Mechanisms of Mitotic Spindle Assembly

Author(s): Petry, Sabine

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Abstract: Life depends on cell proliferation and the accurate segregation of chromosomes, which are mediated by the microtubule (MT)-based mitotic spindle and ~200 essential MT-associated proteins. Yet, a mechanistic understanding of how the mitotic spindle is assembled and achieves chromosome segregation is still missing. This is mostly due to the density of MTs in the spindle, which presumably precludes their direct observation. Recent insight has been gained into the molecular building plan of the metaphase spindle using bulk and single-molecule measurements combined with computational modeling. MT nucleation was uncovered as a key principle of spindle assembly, and mechanistic details about MT nucleation pathways and their coordination are starting to be revealed. Lastly, advances in studying spindle assembly can be applied to address the molecular mechanisms of how the spindle segregates chromosomes.
Publication Date: 2-Jun-2016
Citation: Petry, Sabine. (2016). Mechanisms of Mitotic Spindle Assembly. Annual Review of Biochemistry, 85 (1), 659 - 683. doi:10.1146/annurev-biochem-060815-014528
DOI: doi:10.1146/annurev-biochem-060815-014528
ISSN: 0066-4154
EISSN: 1545-4509
Pages: 659 - 683
Type of Material: Journal Article
Journal/Proceeding Title: Annual Review of Biochemistry
Version: Author's manuscript

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