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Cancer dormancy and criticality from a game theory perspective

Author(s): Wu, Amy; Liao, David; Kirilin, Vlamimir; Lin, Ke-Chih; Torga, Gonzalo; et al

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Abstract: Background: The physics of cancer dormancy, the time between initial cancer treatment and re-emergence after a protracted period, is a puzzle. Cancer cells interact with host cells via complex, non-linear population dynamics, which can lead to very non-intuitive but perhaps deterministic and understandable progression dynamics of cancer and dormancy. Results: We explore here the dynamics of host-cancer cell populations in the presence of (1) payoffs gradients and (2) perturbations due to cell migration. Conclusions: We determine to what extent the time-dependence of the populations can be quantitively understood in spite of the underlying complexity of the individual agents and model the phenomena of dormancy.
Publication Date: 22-Jan-2018
DOI: doi:10.1186/s41236-018-0008-0
EISSN: 2366-6196
Keywords: cancer, dormancy, game theory, perturbations, simulation
Language: en
Type of Material: Journal Article
Journal/Proceeding Title: Cancer Convergence
Version: Final published version. This is an open access article.

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