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Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense

Author(s): Guise, Amanda; Budayeva, Hanna; Diner, Benjamin; Cristea, Ileana

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Abstract: Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based “omic” technologies to infectious disease research, offering a systems biology view of infection.
Publication Date: 27-Jun-2013
Citation: Guise, Amanda, Budayeva, Hanna, Diner, Benjamin, Cristea, Ileana. (2013). Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense. Viruses, 5 (7), 1607 - 1632. doi:10.3390/v5071607
DOI: doi:10.3390/v5071607
EISSN: 1999-4915
Pages: 1607 - 1632
Type of Material: Journal Article
Journal/Proceeding Title: Viruses
Version: Final published version. This is an open access article.

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