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Normal cognitive and social development require posterior cerebellar activity

Author(s): Badura, Aleksandra; Verpeut, Jessica L; Metzger, Julia W; Pereira, Talmo D; Pisano, Thomas J; et al

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Abstract: Cognitive and social capacities require postnatal experience, yet the pathways by which experience guides development are unknown. Here we show that the normal development of motor and nonmotor capacities requires cerebellar activity. Using chemogenetic perturbation of molecular layer interneurons to attenuate cerebellar output in mice, we found that activity of posterior regions in juvenile life modulates adult expression of eyeblink conditioning (paravermal lobule VI, crus I), reversal learning (lobule VI), persistive behavior and novelty-seeking (lobule VII), and social preference (crus I/II). Perturbation in adult life altered only a subset of phenotypes. Both adult and juvenile disruption left gait metrics largely unaffected. Contributions to phenotypes increased with the amount of lobule inactivated. Using an anterograde transsynaptic tracer, we found that posterior cerebellum made strong connections with prelimbic, orbitofrontal, and anterior cingulate cortex. These findings provide anatomical substrates for the clinical observation that cerebellar injury increases the risk of autism.
Publication Date: 20-Sep-2018
Citation: Badura, Aleksandra, Verpeut, Jessica L, Metzger, Julia W, Pereira, Talmo D, Pisano, Thomas J, Deverett, Ben, Bakshinskaya, Dariya E, Wang, Samuel S-H. (Normal cognitive and social development require posterior cerebellar activity. Elife, 7 (10.7554/eLife.36401)
DOI: doi:10.7554/eLife.36401
ISSN: 2050-084X
Pages: e36401 - e36401
Type of Material: Journal Article
Journal/Proceeding Title: eLife
Version: Final published version. This is an open access article.

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