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|Abstract:||Meiotic recombination is a fundamental evolutionary process driving diversity in eukaryotes. In mammals, recombination is known to occur preferentially at specific genomic regions. Using topological data analysis (TDA), a branch of applied topology that extracts global features from large datasets, we developed an efficient method for mapping recombination at fine scales. When compared to standard linkage-based methods, TDA can deal with a larger number of SNPs and genomes without incurring prohibitive computational costs. We applied TDA to 1,000 Genomes Project data and constructed high-resolution whole-genome recombination maps of seven human populations. Our analysis shows that recombination is generally under-represented within transcription start sites. However, the binding sites of specific transcription factors are enriched for sites of recombination. These include transcription factors that regulate the expression of meiosis and game-to-genesis-specific genes, cell cycle progression and differentiation blockage. Additionally, our analysis identifies an enrichment for sites of recombination at repeat-derived loci matched by piwi-interacting RNAs.|
|Citation:||Camara, Pablo G, Rosenbloom, Daniel IS, Emmett, Kevin J, Levine, Arnold J, Rabadan, Raul. (2016). Topological Data Analysis Generates High-Resolution, Genome-wide Maps of Human Recombination. Cell Systems, 3 (1), 83 - 94. doi:10.1016/j.cels.2016.05.008|
|Pages:||83 - 94|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Cell Systems|
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