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The impact of orbitofrontal dysfunction on cocaine addiction

Author(s): Lucantonio, Federica; Stalnaker, Thomas A.; Shaham, Yavin; Niv, Yael; Schoenbaum, Geoffrey

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Abstract: Cocaine addiction is characterized by poor judgment and maladaptive decision-making. Here we review evidence implicating the orbitofrontal cortex in such behavior. This evidence suggests that cocaine-induced changes in orbitofrontal cortex disrupt the representation of states and transition functions that form the basis of flexible and adaptive ‘model-based’ behavioral control. By impairing this function, cocaine exposure leads to an overemphasis on less flexible, maladaptive ‘model-free’ control systems. We propose that such an effect accounts for the complex pattern of maladaptive behaviors associated with cocaine addiction.
Publication Date: Mar-2012
Electronic Publication Date: 22-Jan-2012
Citation: Lucantonio, Federica, Stalnaker, Thomas A, Shaham, Yavin, Niv, Yael, Schoenbaum, Geoffrey. (2012). The impact of orbitofrontal dysfunction on cocaine addiction. Nature Neuroscience, 15 (3), 358 - 366. doi:10.1038/nn.3014
DOI: doi:10.1038/nn.3014
ISSN: 1097-6256
EISSN: 1546-1726
Pages: 358 - 366
Type of Material: Journal Article
Journal/Proceeding Title: Nature Neuroscience
Version: Author's manuscript

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