To refer to this page use:
|Abstract:||Cocaine addiction is characterized by poor judgment and maladaptive decision-making. Here we review evidence implicating the orbitofrontal cortex in such behavior. This evidence suggests that cocaine-induced changes in orbitofrontal cortex disrupt the representation of states and transition functions that form the basis of flexible and adaptive ‘model-based’ behavioral control. By impairing this function, cocaine exposure leads to an overemphasis on less flexible, maladaptive ‘model-free’ control systems. We propose that such an effect accounts for the complex pattern of maladaptive behaviors associated with cocaine addiction.|
|Electronic Publication Date:||22-Jan-2012|
|Citation:||Lucantonio, Federica, Stalnaker, Thomas A, Shaham, Yavin, Niv, Yael, Schoenbaum, Geoffrey. (2012). The impact of orbitofrontal dysfunction on cocaine addiction. Nature Neuroscience, 15 (3), 358 - 366. doi:10.1038/nn.3014|
|Pages:||358 - 366|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Nature Neuroscience|
Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.