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Rotate into shape: MreB and bacterial morphogenesis

Author(s): van Teeffelen, Sven; Gitai, Zemer

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Abstract: MreB, the bacterial actin homologue, plays a vital role in determining cell shape, but the mechanisms by which it actually functions have remained largely mysterious. Recent studies now shed new light on MreB, demonstrating that it associates with many cell‐wall synthesis enzymes, including a newly identified family of proteins that mediate teichoic acid synthesis in Gram‐positive bacteria. Furthermore, MreB filaments dynamically rotate around the cell circumference in a manner dependent on the cell‐wall assembly machinery. Thus, MreB may function to spatially organize the enzymatic activities required for proper bacterial growth (see Figure 1).
Publication Date: 14-Dec-2011
Electronic Publication Date: 14-Dec-2011
Citation: van Teeffelen, Sven, Gitai, Zemer. (2011). Rotate into shape: MreB and bacterial morphogenesis. The EMBO Journal, 30 (24), 4856 - 4857. doi:10.1038/emboj.2011.430
DOI: doi:10.1038/emboj.2011.430
ISSN: 0261-4189
Pages: 4856 - 4857
Type of Material: Journal Article
Journal/Proceeding Title: The EMBO Journal
Version: Final published version. This is an open access article.

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