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GAGA factor: a multifunctional pioneering chromatin protein

Author(s): Chetverina, Darya; Erokhin, Maksim; Schedl, Paul D

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Abstract: The Drosophila GAGA factor (GAF) is a multifunctional protein implicated in nucleosome organization and remodeling, activation and repression of gene expression, long distance enhancer-promoter communication, higher order chromosome structure and mitosis. This broad range of activities poses questions about how a single protein can perform so many seemingly different and unrelated functions. Current studies argue that GAF acts as a “pioneer” factor, generating nucleosome free regions of chromatin for different classes of regulatory elements. The removal of nucleosomes from regulatory elements in turn enables other factors to bind to these elements and carry out their specialized functions. Consistent with this view, GAF associates with a collection of chromatin remodelers and also interacts with proteins implicated in different regulatory functions. In this review, we summarize the known activities of GAF and the functions of its protein partners.
Publication Date: 1-May-2022
DOI: doi:10.1007/s00018-021-03776-z
ISSN: 1420-682X
EISSN: 1420-9071
Keywords: GAF, pioneer factor, promoter regulation, boundary protein, Polycomb, chromatin silencing, GAGA, promoter, architectural protein, insulator, transcription regulation
Language: en
Type of Material: Journal Article
Journal/Proceeding Title: Cellular and Molecular Life Sciences
Version: Author's manuscript

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