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|Abstract:||Mid-infrared transmission spectroscopy using broadband midinfrared or Quantum Cascade laser sources is used to predict glucose concentrations of aqueous and serum solutions containing physiologically relevant amounts of glucose (50-400 mg/dL). We employ partial least squares regression to generate a calibration model using a subset of the spectra taken and to predict concentrations from new spectra. Clinically accurate measurements with respect to a Clarke error grid were made for concentrations as low as 30 mg/dL, regardless of background solvent. These results are an important and encouraging step in the work towards developing a noninvasive in vivo glucose sensor in the mid-infrared.|
|Electronic Publication Date:||11-Jun-2013|
|Citation:||Liakat, S, Bors, KA, Huang, T-Y, Michel, APM, Zanghi, E, Gmachl, CF. (2013). In vitro measurements of physiological glucose concentrations in biological fluids using mid-infrared spectroscopy|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Biomedical Optics Express|
|Version:||Final published version. Article is made available in OAR by the publisher's permission or policy.|
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