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|Abstract:||Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.|
|Electronic Publication Date:||20-Jun-2016|
|Citation:||Sabass, Benedikt, Stone, Howard A. (2016). Role of the Membrane for Mechanosensing by Tethered Channels. Physical Review Letters, 116 (25), 10.1103/PhysRevLett.116.258101|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Physical Review Letters|
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