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Fluid dynamics in zebrafish Kupffer's vesicle

Author(s): Okabe, Noriko; Xu, Bo; Burdine, Rebecca

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dc.contributor.authorOkabe, Noriko-
dc.contributor.authorXu, Bo-
dc.contributor.authorBurdine, Rebecca-
dc.date.accessioned2022-01-25T14:57:43Z-
dc.date.available2022-01-25T14:57:43Z-
dc.date.issued2008en_US
dc.identifier.citationOkabe, Noriko, Burdine, Rebecca D. (2008). Fluid dynamics in zebrafish Kupffer's vesicle. Developmental Biology, 319 (2), 579 - 579. doi:10.1016/j.ydbio.2008.05.398en_US
dc.identifier.issn0012-1606-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1ff3m00f-
dc.description.abstractWork in mouse has implicated cilia motility and leftward nodal flow as the mechanism for breaking symmetry. In zebrafish, it is assumed that Kupffer’s vesicle is analogous to the mouse node. However, its architecture is different and the fluid dynamics inside Kupffer’s vesicle is not completely understood. We show that cells lining both the dorsal roof and the ventral floor of Kupffer’s vesicle possess posteriorly pointed cilia that rotate clockwise. Analysis of bead movements within Kupffer’s vesicle shows a net circular flow but the local flow differs in direction depending on the location within the vesicle. Histological analysis suggests that the orientation of the cells at anterior-dorsal region likely direct net flow in the vesicle. Our data suggest that the plane of the circular net flow is tilted with respect to the D-V axis, which may be converted to a local leftward flow in the anteriordorsal region of the vesicle.en_US
dc.format.extent3602-3612en_US
dc.language.isoen_USen_US
dc.relation.ispartofDevelopmental Biologyen_US
dc.rightsFinal published version. Article is made available in OAR by the publisher's permission or policy.en_US
dc.titleFluid dynamics in zebrafish Kupffer's vesicleen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1016/j.ydbio.2008.05.398-
dc.date.eissued2008-11-20en_US
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/conference-proceedingen_US

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