To refer to this page use:
|Abstract:||Using the amber suppression approach, four noncanonical amino acids (ncAAs) were used to replace existing amino acids at four positions in lasso peptide microcin J25 (MccJ25). The lasso peptide biosynthesis enzymes tolerated all four ncAAs and produced antibiotics with efficacy equivalent to wild-type in some cases. Given the rapid expansion of the genetically encoded ncAA pool, this study is the first to demonstrate an expedient method to significantly increase the chemical diversity of lasso peptides.|
|Electronic Publication Date:||2015|
|Citation:||Piscotta, Frank J, Tharp, Jeffery M, Liu, Wenshe R, Link, A James. (2015). Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids. Chemical Communications, 51 (2), 409 - 412. doi:10.1039/C4CC07778D|
|Pages:||409 - 412|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Chemical Communications|
Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.