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|Abstract:||This paper presents the results of an experimental study of the effects of adhesion between gold nanoparticles and surfaces that are relevant to the potential applications in cancer detection and treatment. Adhesion is measured using a dip coating/atomic force microscopy (DC/AFM) technique. The adhesion forces are obtained for dip-coated gold nanoparticles that interact with peptide or antibody-based molecular recognition units (MRUs) that attach specifically to breast cancer cells. They include MRUs that attach specifically to receptors on breast cancer cells. Adhesion forces between anti-cancer drugs such as paclitaxel, and the constituents of MRU-conjugated Au nanoparticle clusters, are measured using force microscopy techniques. The implications of the results are then discussed for the design of robust gold nanoparticle clusters and for potential applications in localized drug delivery and hyperthermia.|
|Citation:||Oni, Y., K. Hao, S. Dozie-Nwachukwu, J. D. Obayemi, O. S. Odusanya, N. Anuku, and W. O. Soboyejo. "Gold nanoparticles for cancer detection and treatment: The role of adhesion." Journal of Applied Physics 115, no. 8 (2014): 084305. doi: 10.1063/1.4863541|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Journal of Applied Physics|
|Version:||Final published version. Article is made available in OAR by the publisher's permission or policy.|
|Notes:||This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Oni, Y., K. Hao, S. Dozie-Nwachukwu, J. D. Obayemi, O. S. Odusanya, N. Anuku, and W. O. Soboyejo. "Gold nanoparticles for cancer detection and treatment: The role of adhesion." Journal of Applied Physics 115, no. 8 (2014): 084305. and may be found at http://dx.doi.org/10.1063/1.4863541|
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