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|Abstract:||Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.|
|Citation:||Gibney, Patrick A, Schieler, Ariel, Chen, Jonathan C, Bacha-Hummel, Jessie M, Botstein, Maxim, Volpe, Matthew, Silverman, Sanford J, Xu, Yifan, Bennett, Bryson D, Rabinowitz, Joshua D, Botstein, David. (2018). Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.. Molecular biology of the cell, 29 (8), 897 - 910. doi:10.1091/mbc.E17-11-0666|
|Pages:||897 - 910|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Molecular biology of the cell|
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