The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress
Author(s): Shor, Erika; Fox, Catherine A; Broach, James R
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Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shor, Erika | - |
dc.contributor.author | Fox, Catherine A | - |
dc.contributor.author | Broach, James R | - |
dc.date.accessioned | 2020-02-25T20:11:14Z | - |
dc.date.available | 2020-02-25T20:11:14Z | - |
dc.date.issued | 2013-08-01 | en_US |
dc.identifier.citation | Shor, Erika, Fox, Catherine A, Broach, James R. (2013). The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress. PLoS Genetics, 9 (8), e1003680 - e1003680. doi:10.1371/journal.pgen.1003680 | en_US |
dc.identifier.uri | http://arks.princeton.edu/ark:/88435/pr13v1n | - |
dc.description.abstract | Conditions of chronic stress are associated with genetic instability in many organisms, but the roles of stress responses in mutagenesis have so far been elucidated only in bacteria. Here, we present data demonstrating that the environmental stress response (ESR) in yeast functions in mutagenesis induced by proteotoxic stress. We show that the drug canavanine causes proteotoxic stress, activates the ESR, and induces mutagenesis at several loci in an ESR-dependent manner. Canavanine-induced mutagenesis also involves translesion DNA polymerases Rev1 and Polf and non-homologous end joining factor Ku. Furthermore, under conditions of chronic sub-lethal canavanine stress, deletions of Rev1, Polf, and Kuencoding genes exhibit genetic interactions with ESR mutants indicative of ESR regulating these mutagenic DNA repair processes. Analyses of mutagenesis induced by several different stresses showed that the ESR specifically modulates mutagenesis induced by proteotoxic stress. Together, these results document the first known example of an involvement of a eukaryotic stress response pathway in mutagenesis and have important implications for mechanisms of evolution, carcinogenesis, and emergence of drug-resistant pathogens and chemotherapy-resistant tumors. | en_US |
dc.format.extent | 1 - 14 | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | PLoS Genetics | en_US |
dc.rights | Final published version. This is an open access article. | en_US |
dc.title | The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | doi:10.1371/journal.pgen.1003680 | - |
dc.date.eissued | 2013-08-01 | en_US |
dc.identifier.eissn | 1553-7404 | - |
pu.type.symplectic | http://www.symplectic.co.uk/publications/atom-terms/1.0/journal-article | en_US |
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The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress.PDF | 2.46 MB | Adobe PDF | View/Download |
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