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Connecting Neural Codes with Behavior in the Auditory System of Drosophila

Author(s): Clemens, Jan; Girardin, Cyrille C; Coen, Philip; Guan, Xiao-Juan; Dickson, Barry J; et al

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dc.contributor.authorClemens, Jan-
dc.contributor.authorGirardin, Cyrille C-
dc.contributor.authorCoen, Philip-
dc.contributor.authorGuan, Xiao-Juan-
dc.contributor.authorDickson, Barry J-
dc.contributor.authorMurthy, Mala-
dc.date.accessioned2023-12-12T16:09:59Z-
dc.date.available2023-12-12T16:09:59Z-
dc.date.issued2015-09-23en_US
dc.identifier.citationClemens, Jan, Girardin, Cyrille C, Coen, Philip, Guan, Xiao-Juan, Dickson, Barry J, Murthy, Mala. (2015). Connecting Neural Codes with Behavior in the Auditory System of Drosophila. Neuron, 87 (6), 1332 - 1343. doi:10.1016/j.neuron.2015.08.014en_US
dc.identifier.issn0896-6273-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr13b5w778-
dc.description.abstractBrains are optimized for processing ethologically relevant sensory signals. However, few studies have characterized the neural coding mechanisms that underlie the transformation from natural sensory information to behavior. Here, we focus on acoustic communication in Drosophila melanogaster, and use computational modeling to link natural courtship song, neuronal codes, and female behavioral responses to song. We show that melanogaster females are sensitive to long timescale song structure (on the order of tens of seconds). From intracellular recordings, we generate models that recapitulate neural responses to acoustic stimuli. We link these neural codes with female behavior by generating model neural responses to natural courtship song. Using a simple decoder, we predict female behavioral responses to the same song stimuli with high accuracy. Our modeling approach reveals how long timescale song features are represented by the Drosophila brain, and how neural representations can be decoded to generate behavioral selectivity for acoustic communication signals.en_US
dc.format.extent1332 - 1343en_US
dc.language.isoen_USen_US
dc.relation.ispartofNeuronen_US
dc.rightsAuthor's manuscripten_US
dc.titleConnecting Neural Codes with Behavior in the Auditory System of Drosophilaen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1016/j.neuron.2015.08.014-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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