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|Abstract:||Spatial patterns in the early fruit fly embryo emerge from a network of interactions among transcription factors, the gap genes, driven by maternal inputs. Such networks can exhibit many qualitatively different behaviors, separated by critical surfaces. At criticality, we should observe strong correlations in the fluctua- tions of different genes around their mean expression levels, a slowing of the dynamics along some but not all directions in the space of possible expression levels, correlations of expression fluctuations over long distances in the embryo, and departures from a Gaussian distribution of these fluctuations. Analysis of recent ex- periments on the gap gene network shows that all these signatures are observed, and that the differe nt signatures are related in ways predicted by theory. Although there might be other explanations for these individual phenomena, the confluence of evidence suggests that this genetic network is tuned to criticality.|
|Electronic Publication Date:||10-Feb-2014|
|Citation:||Krotov, Dmitry, Dubuis, Julien O, Gregor, Thomas, Bialek, William. (2014). Morphogenesis at criticality. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111 (3683 - 3688. doi:10.1073/pnas.1324186111|
|Pages:||3683 - 3688|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA|
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