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Eleven grand challenges in single-cell data science.

Author(s): Lähnemann, David; Köster, Johannes; Szczurek, Ewa; McCarthy, Davis J; Hicks, Stephanie C; et al

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dc.contributor.authorLähnemann, David-
dc.contributor.authorKöster, Johannes-
dc.contributor.authorSzczurek, Ewa-
dc.contributor.authorMcCarthy, Davis J-
dc.contributor.authorHicks, Stephanie C-
dc.contributor.authorRobinson, Mark D-
dc.contributor.authorVallejos, Catalina A-
dc.contributor.authorCampbell, Kieran R-
dc.contributor.authorBeerenwinkel, Niko-
dc.contributor.authorMahfouz, Ahmed-
dc.contributor.authorPinello, Luca-
dc.contributor.authorSkums, Pavel-
dc.contributor.authorStamatakis, Alexandros-
dc.contributor.authorAttolini, Camille Stephan-Otto-
dc.contributor.authorAparicio, Samuel-
dc.contributor.authorBaaijens, Jasmijn-
dc.contributor.authorBalvert, Marleen-
dc.contributor.authorBarbanson, Buys de-
dc.contributor.authorCappuccio, Antonio-
dc.contributor.authorCorleone, Giacomo-
dc.contributor.authorDutilh, Bas E-
dc.contributor.authorFlorescu, Maria-
dc.contributor.authorGuryev, Victor-
dc.contributor.authorHolmer, Rens-
dc.contributor.authorJahn, Katharina-
dc.contributor.authorLobo, Thamar Jessurun-
dc.contributor.authorKeizer, Emma M-
dc.contributor.authorKhatri, Indu-
dc.contributor.authorKielbasa, Szymon M-
dc.contributor.authorKorbel, Jan O-
dc.contributor.authorKozlov, Alexey M-
dc.contributor.authorKuo, Tzu-Hao-
dc.contributor.authorLelieveldt, Boudewijn PF-
dc.contributor.authorMandoiu, Ion I-
dc.contributor.authorMarioni, John C-
dc.contributor.authorMarschall, Tobias-
dc.contributor.authorMölder, Felix-
dc.contributor.authorNiknejad, Amir-
dc.contributor.authorRaczkowski, Lukasz-
dc.contributor.authorReinders, Marcel-
dc.contributor.authorRidder, Jeroen de-
dc.contributor.authorSaliba, Antoine-Emmanuel-
dc.contributor.authorSomarakis, Antonios-
dc.contributor.authorStegle, Oliver-
dc.contributor.authorTheis, Fabian J-
dc.contributor.authorYang, Huan-
dc.contributor.authorZelikovsky, Alex-
dc.contributor.authorMcHardy, Alice C-
dc.contributor.authorRaphael, Benjamin J-
dc.contributor.authorShah, Sohrab P-
dc.contributor.authorSchönhuth, Alexander-
dc.date.accessioned2021-10-08T19:47:11Z-
dc.date.available2021-10-08T19:47:11Z-
dc.date.issued2020-02-07en_US
dc.identifier.citationLähnemann, David, Köster, Johannes, Szczurek, Ewa, McCarthy, Davis J, Hicks, Stephanie C, Robinson, Mark D, Vallejos, Catalina A, Campbell, Kieran R, Beerenwinkel, Niko, Mahfouz, Ahmed, Pinello, Luca, Skums, Pavel, Stamatakis, Alexandros, Attolini, Camille Stephan-Otto, Aparicio, Samuel, Baaijens, Jasmijn, Balvert, Marleen, Barbanson, Buys de, Cappuccio, Antonio, Corleone, Giacomo, Dutilh, Bas E, Florescu, Maria, Guryev, Victor, Holmer, Rens, Jahn, Katharina, Lobo, Thamar Jessurun, Keizer, Emma M, Khatri, Indu, Kielbasa, Szymon M, Korbel, Jan O, Kozlov, Alexey M, Kuo, Tzu-Hao, Lelieveldt, Boudewijn PF, Mandoiu, Ion I, Marioni, John C, Marschall, Tobias, Mölder, Felix, Niknejad, Amir, Raczkowski, Lukasz, Reinders, Marcel, Ridder, Jeroen de, Saliba, Antoine-Emmanuel, Somarakis, Antonios, Stegle, Oliver, Theis, Fabian J, Yang, Huan, Zelikovsky, Alex, McHardy, Alice C, Raphael, Benjamin J, Shah, Sohrab P, Schönhuth, Alexander. (2020). Eleven grand challenges in single-cell data science.. Genome biology, 21 (1), 31 - ?. doi:10.1186/s13059-020-1926-6en_US
dc.identifier.issn1474-7596-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr10g1f-
dc.description.abstractThe recent boom in microfluidics and combinatorial indexing strategies, combined with low sequencing costs, has empowered single-cell sequencing technology. Thousands-or even millions-of cells analyzed in a single experiment amount to a data revolution in single-cell biology and pose unique data science problems. Here, we outline eleven challenges that will be central to bringing this emerging field of single-cell data science forward. For each challenge, we highlight motivating research questions, review prior work, and formulate open problems. This compendium is for established researchers, newcomers, and students alike, highlighting interesting and rewarding problems for the coming years.en_US
dc.format.extent31 - ?en_US
dc.languageengen_US
dc.language.isoen_USen_US
dc.relation.ispartofGenome biologyen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleEleven grand challenges in single-cell data science.en_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1186/s13059-020-1926-6-
dc.identifier.eissn1474-760X-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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